Survival Analysis Solution Manual Klein And Moeschberger
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The results of this study document a persistent and consistent loss of filtration efficiency over time for BSFs as compared with FDA-approved POU filters. The survival function, which is an estimate of the rate of failure to be used, is a measure of sustainability. This study presents the first utilization of the KM method of survival analysis to assess sustainability of POU filters. From a sustainability perspective, this study is also the first to assess the sustainability of BSFs.
For this study, a sequence of Kaplan-Meier estimates of the survivor function for duration of use were calculated for different pairs of treatment groups. A paired comparison was undertaken by subtracting the two consecutive Kaplan-Meier survival curves for a given pair of treatment groups and evaluating the resulting increase in the survivor function. This difference in survivor functions is known as the KM estimate of the survivor function.17, 20, 21
If the BSFs do not provide sufficient protection against blood-borne viruses to meet the standards of the blood and tissue banking industry, then patients who use the BSFs should be protected against transfusion-transmitted infections, and blood suppliers should be protected against blood donor-derived infections. The present analysis estimated the proportion of patients who would be infected with hepatitis C and/or HIV if they used a BSF for their hemodialysis treatment.
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