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OBJECTIVE: To verify the role of histopathological features in the prognosis of gastric carcinoma. METHODS: Four hundred and forty-seven patients with gastric cancer, undergoing surgical treatment at the Esophageal Cancer Department of the Escola Paulista de Medicina da Universidade Federal de São Paulo, were evaluated. The histopathological features were analyzed and the variables associated with 5-year survival were identified. RESULTS: Among the analyzed characteristics, the depth of invasion, lymph node metastasis, vascular invasion, and poor differentiation were the most important factors related to mortality. CONCLUSIONS: We verified that the depth of invasion, lymph node metastasis, vascular invasion, and poor differentiation are the most important factors related to mortality.
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